منابع مشابه
Actin cytoskeleton: Putting a CAP on actin polymerization
Two recent studies have identified a Drosophila homolog of cyclase-associated protein (CAP) as a developmentally important negative regulator of actin polymerization that may also directly mediate signal transduction.
متن کاملActin Nucleation: Putting the Brakes on Arp2/3
The Arp2/3 complex is a powerful nucleator of actin filaments when activated. A recent study has now revealed that this complex is not only subject to positive control but that there also exists a brake on its activity. This brake can suppress both the basal activity of the Arp2/3 complex as well as its activation by nucleation-promoting factors.
متن کاملMechanism and Function of Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7: A Dissertation
Enterohemorrhagic Escherichia coli O157:H7 (EHEC) and enteropathogenic E. coli O127:H7 (EPEC) induce characteristic F-actin rich pedestals on infected mammalian cells. Each pathogen delivers its own translocated intimin receptor (Tir) to the host cell to act as a receptor for the bacterial outer membrane adhesin, intimin. Interaction of translocated Tir with intimin is essential for mammalian c...
متن کاملThe Organization of Actin Filaments
Within each tapering stereocilium of the cochlea of the alligator lizard is a bundle of actin filaments with >3,000 filaments near the tip and only 18-29 filaments at the base where the bundle enters into the cuticular plate; there the filaments splay out as if on the surface of a cone, forming the rootlet. Decoration of the hair cells with subfragment 1 of myosin reveals that all the filaments...
متن کاملSome observations on the pedestal effect.
The pedestal or dipper effect is the large improvement in the detectability of a sinusoidal grating observed when it is added to a masking or pedestal grating of the same spatial frequency, orientation, and phase. We measured the pedestal effect in both broadband and notched noise-noise from which a 1.5-octave band centered on the signal frequency had been removed. Although the pedestal effect ...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 1999
ISSN: 1465-7392,1476-4679
DOI: 10.1038/14092